Erectile Dysfunction is a common sexual disorder with a multidimensional aspect involving changes in the erectile response of the individual because of systemic or psychological conditions. Defined as an inability to achieve or maintain an erection sufficient for satisfactory sexual performance and affects people of all age groups but is especially evident in the age group of 40-70. It is essential to understand the pathophysiology of erection and erectile dysfunction to understand Kamagra 100mg better.
Pathophysiology of erection and erectile dysfunction
Erection can be safely considered to be a neurovascular event of the human body that depends to a significant extent on sexual stimulation, a combination of hormonal and psychological conditions. Once an individual has been sexually stimulated, the brain releases neurotransmitters from its nerve terminals that relax the endothelial cells of the penis. This relaxes the arterial muscles and arterioles supplying the erectile tissue composed of elastic fibers, collagen fibers, smooth muscles, arteries, and veins and facilitates the erection
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The penis tends to stay in a flaccid or soft state until its muscles are contracted. Smooth muscle contraction is regulated by adrenergic control, intrinsic myogenic control, and endothelium-derived contracting factors of the system. Upon sexual stimulation, an erection occurs after nitric oxide (NO) is released from non-adrenergic non-cholinergic (NANC) nerve fibers, and acetylcholine is released from nerve fibers.
This increases the concentrations of cyclic Guanosine Monophosphate ( an intracellular messenger responsible for penile vascular tone with a decrease in the levels of intracellular Ca2+ levels that relax the corpus cavernosum ( tissue constituting the bulk of the penis ), subsequently regulating a successful erection. During this time, the subtunical venules are compressed to cause venous occlusion. Hydrolysation of the cGMP concentrations as a result of pathophysiological conditions reverses the erection cycle and improves venous outflow resulting in symptoms of erectile dysfunction.
Mechanism of action of Kamagra Sildenafil 100mg
Buy Kamagra 100mg tablets is a generic version of Sildenafil that is a selective inhibitor of cyclic GMP-specific phosphodiesterase PDE enzymes. Sildenafil is highly selective on PDE 5 and PDE 6 enzymes compared to PDE 1, 2, 3, and 4. PDE 5 plays an important role in metabolizing cyclic GMP in the corpus cavernosum, the sponge-like region of the erectile tissue responsible for the vascular process during an erection. When sexual stimulation causes the local release of Nitric oxide, inhibition of PDE 5 by sildenafil causes increased levels of cyclic-GMP in the corpus cavernosum, resulting in smooth muscle relaxation and, subsequently, a successful erection period uninterrupted by physiological problems.
Image credit – https://www.frontiersin.org/articles/10.3389/fonc.2021.627229/full
Kamagra is the recently introduced derivative of Sildenafil and shares the same pharmacological properties and therapeutic properties as Sildenafil and Viagra. In addition to managing conditions of erectile dysfunction, it facilitates the vascular health of individuals on a lower dose and improves their stamina with exercising capacity. Kamagra is available in strengths of 50 and 100mg, of which physicians initially advise lower doses before switching to higher strengths of the medication.
What do studies say about Kamagra 100mg?
In a study was conducted to assess the tolerability and efficacy of Sildenafil initiated at a 100-mg dose in men with ED, selected participants were approved for the study. Inclusion criteria had subjects that had received six or more total doses of a phosphodiesterase type 5 inhibitor and were randomized to 8 weeks of a double-blind, placebo-controlled (DBPC)study. There was a fixed-dose treatment of 50 or 100 mg sildenafil or placebo followed by four weeks of open-label flexible-dose Sildenafil 50 or 100 mg. Efficacy, tolerability, treatment satisfaction, and other parameters were compared to reach a conclusion regarding the efficacy of Sildenafil in terms of dose and placebo treatment.
The results proved a statistically significant improvement in patient outcome in both 50mg and 100mg doses of Sildenafil as compared to placebo. 56% of men on a 100mg dose reported a decrease in anxiety regarding their erectile status as compared to 39% using 50mg of the medication. Changes in functional scores from baseline were not statistically significant in either strength. Treatment satisfaction and sexual experience scores were improved with 100mg of Sildenafil. Adverse events did not increase on increasing the strength of the medication.
What can go wrong with Kamagra 100mg
The problem in using Kamagra 100 lies less in the strength of the medication than in the availability of genuine versions for supply to the patient. Statistics have shown approximately 2.5 million people in Europe and America are exposed to illegally obtained Sildenafil, which, when used injudiciously, can lead to several adverse reactions ranging from ineffective treatment to permanently impaired erectile function. Spurious Sildenafil further adds to the problem. An analysis of spurious Sildenafil derivatives has found inconsistent doses of pharmaceutical ingredients with other added contaminants, including talcum powder, printer ink, and even commercial paint, that can prove lethal to the patient. In one analysis, only 10.1% of the samples were included in the ingredient contents. Counterfeit Sildenafil not just poses a threat to the individual’s health but even impacts the progress of the healthcare system.
Kamagra 100 mg can effectively curb your problem of erectile dysfunction, provided it is used judiciously. Using Kamagra 100 improves erectile dysfunction problems to a satisfactory extent by improving the user’s stamina and self-esteem. Care should be taken to ensure its authenticity for patient safety.